FAQ

Frequently ask questions

Below you find comprehensive and easy-to-understand answers to the most frequently asked questions about the PrenaTest®. Simply click on a question to go directly to the answer or scroll down to read all FAQs.

 

What can the PrenaTest® detect in my child?

The PrenaTest® is known as a non-invasive prenatal test (NIPT). From maternal blood, it can detect the following changes in the genetic material of your unborn child, known as chromosomal disorders:

 

Trisomy 21 (Down syndrome)

Trisomy 18 ( Edwards syndrome)

Trisomy 13 (Patau syndrome)

Maldistributions of the sex chromosomes X and Y (Turner, triple X, Klinefelter and XYY syndrome)

22q11.2 microdeletion (DiGeorge syndrome)

 

If desired, you can also learn whether you are expecting a girl or a boy. In Germany, in accordance with statutory provisions, your doctor will tell you the sex of your child starting from the twelfth week of pregnancy post-conception. National regulations in other countries may vary.

What is the PrenaTest® unable to detect in my child?

Certain special forms of chromosomal disorders, for example, structural changes to chromosomes or mosaics, cannot be detected. In the case of structural chromosomal disorders, a piece of a chromosome is missing, there is an extra piece or a piece was incorporated incorrectly in the chromosome. In a mosaic, cells of a tissue or of the entire organism of the embryo have different genetic information.

 

How accurate is the PrenaTest®?

The high degree of accuracy of the PrenaTest® has been proven in many clinical studies. In addition, the test was approved by an independent test center which acts on behalf of public authorities. The studies show, that in 99,8% of all blood samples from single pregrancies, the test result of the PrenaTest® for the detection of trisomies 13,18 and 21 was correct. This means that out of 1000 blood samples tested, 998 results were correctly determined. The test quality was also verified in the case of twin pregnancies. Here as well, the result was correct for all blood samples tested. The accuracy of the PrenaTest® to detect maldistributions of sex chromosomes (X/Y) is somewhat lower than for the detection of trisomies 13,18 and 21. In another clinical study, the 22q11.2 microdeletion was also correctly detected in all blood samples.

 

Should I have the PrenaTest® performed?

In principle, the PrenaTest® is suitable for all pregnant women. You and your doctor can discuss together whether the test is also appropriate for you. Many women choose to undergo the PrenaTest® because of their age or because they are concerned about prior abnormal test results. Talk to your doctor about which of the test options is advisable for you in your personal situation.

 

When can I have the PrenaTest® performed?

You can undergo the PrenaTest® after the ninth week of pregnancy has been completed (week 9+0 since LMP). Discuss with your doctor when the test would be most advisable for you personally.

 

Can the PrenaTest® also be performed in the case of a twin pregnancy or after a fertility treatment?

The PrenaTest® can also be performed in the case of a twin pregnancy, following fertility treatment (following IVF or ICSI) as well as after egg donation.

 

What does the PrenaTest® cost?

The cost depends on the scope of the selected test. Discuss with your doctor which chromosomal disorders may be of significance for you. Payment is made via direct debit. The amount will not be debited until the test result has been forwarded to your doctor.

 

Can be used in the case of / followingPrenaTest® Option 1
Trisomy 21,
gender determination
PrenaTest® Option 2
Trisomies 21, 18, 13,
gender determination
PrenaTest® Option 3
Trisomies 21, 18, 13,
Maldistribution of the
sex chromosomes,
22q11.2 microdeletion
gender determination
Single pregnancy
Twin pregnancy
All fertility treatments
(IVF, ICSI etc.)
Test result for option 1 usually in 2 – 6 business days**.
Test result for option 2 & 3 usually in 4 – 6 business days**.
Will my health insurance plan cover the costs of the PrenaTest®?

The PrenaTest® is known as a self-pay service. This means that you must pay the charges yourself. However, private as well as statutory health insurance plans have already paid for the costs in many individual cases. Therefore you must clarify whether your health insurance plan will also cover the costs, if applicable. At www.lifecodexx.com you will find step-by-step instructions (applicable for Germany) and many useful templates to help you.

 

I would like to have the PrenaTest® performed. What´s the next step?

Information, counseling, blood sampling

First your doctor will provide you with comprehensive and unbiased counseling and information in accordance with national regulations. After you provide your written consent for the genetic testing, blood will drawn from a vein in your arm.

 

Laboratory analysis

The analysis begins once the blood sample is received by the laboratory and after it has successfully undergone a quality control inspection.

 

Test result

Your doctor will be informed of the test result immediately after the analysis is completed. He or she will then explain the result to you and discuss the next step with you.

 

When do I receive the test result and how should I interpret it?

The test result will be sent to your doctor within a few business days. If the measured analysis values of the chromosome examined in each case are within normal limits, this means that it is highly likely that the corresponding chromosomal disorder is not present in your unborn child (negative test result). Nonetheless, your doctor will track the rest of your pregnancy closely. If the measured analysis values of the chromosome examined in each case are outside of normal limits, this means that it is highly likely that your unborn child has the chromosomal disorder in question (positive test result). Based on your doctor´s recommendation, the test result should then be diagnostically clarified further.

 

Where is the PraenaTest ® performed?

Since its introduction in August 2012, the PrenaTest® has been completely performed in Germany. The PrenaTest® is currently being performed at three locations Konstanz, Cologne and Munich.

 

 

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